Biological projects using single-cell proteomics

Research areas Perspectives Reviews

Research areas

• Immunology
  • Macrophage polarization: Specht et al, 2019, Huffman et al, 2022
• Normal physiology
  • Cell division cycle: Leduc et al, 2011, 2012, Derks et al, 2022
  • Post-transcriptional regulation: Budnik et al, 2017, Specht et al, 2019
• Cancer biology
  • Drug resistance: Leduc et al, 2012
  • Epithelial-mesenchymal transition: Khan et al., 2023
• Development
  • Stem cell differentiation: Budnik et al, 2017

Perspectives

• Single-cell proteomics: quantifying post-transcriptional regulation, Development
• Learning from natural variation across the proteomes of single cells, PLOS Biology
• Unpicking the proteome in single cells, Science
• Transformative Opportunities for Single-Cell Proteomics, Journal of Proteome Research

Reviews

• Single cell protein analysis for systems biology, Essays in biochemistry
• Scaling up single-cell proteomics, Molecular and Cellular Proteomics

Funding support

The research reported here has been supported by funding from the NIH Director’s Award by an Allen Distinguished Investigator Award from the Paul G. Allen Frontiers Group and by CZI.